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Batch correction of microarray data substantially improves the identification of genes differentially expressed in rheumatoid arthritis and osteoarthritis

Created at: 24/07/2013 @ 11:13:25    
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Projects: LINCONET

BMC Med Genomics
8th June 2012

Peter Kupfer, Guthke Reinhard, Pohlers Dirk, Huber Rene, Koczan Dirk, Kinne Raimund W

Abstract:

Batch effects due to sample preparation or array variation (type, charge, and/or platform) may influence the results of microarray experiments and thus mask and/or confound true biological differences. Of the published approaches for batch correction, the algorithm "Combating Batch Effects When Combining Batches of Gene Expression Microarray Data" (ComBat) appears to be most suitable for small sample sizes and multiple batches.

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